Recombinant Human FRS2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: FRS2-3091H
• Product Overview: FRS2 MS Standard C13 and N15-labeled recombinant protein (NP_006645) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 57.5 kDa
• AA Sequence: MGSCCSCPDKDTVPDNHRNKFKVIN VDDDGNELGSGIMELTDTELILYTR KRDSVKWHYLCLRRYGYDSNLFSFE SGRRCQTGQGIFAFKCARAEELFNM LQEIMQNNSINVVEEPVVERNNHQT ELEVPRTPRTPTTPGFAAQNLPNGY PRYPSFGDASSHPSSRHPSVGSARL PSVGEESTHPLLVAEEQVHTYVNTT GVQEERKNRTSVHVPLEARVSNAES STPKEEPSSIEDRDPQILLEPEGVK FVLGPTPVQKQLMEKEKLEQLGRDQ VSGSGANNTEWDTGYDSDERRDAPS VNKLVYENINGLSIPSASGVRRGRL TSTSTSDTQNINNSAQRRTALLNYE NLPSLPPVWEARKLSRDEDDNLGPK TPSLNGYHNNLDPMHNYVNTENVTV PASAHKIEYSRRRDCTPTVFNFDIR RPSLEHRQLNYIQVDLEGGSDSDNP QTPKTPTTPLPQTPTRRTELYAVID IERTAAMSNLQKALPRDDGTSRKTR HNSTDLPMLAWKTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: FRS2 fibroblast growth factor receptor substrate 2 [ Homo sapiens (human) ]
• Official Symbol: FRS2
• Synonyms: FRS2; fibroblast growth factor receptor substrate 2; FRS2A; FRS2alpha; SNT 1; SNT1; FGFR substrate 2; FGFR signalling adaptor; FGFR-signaling adaptor SNT; suc1-associated neurotrophic factor target 1; SNT; SNT-1
• Gene ID: 10818
• mRNA Refseq: NM_006654
• Protein Refseq: NP_006645
• MIM: 607743
• UniProt ID: Q8WU20