Recombinant Human FRS3, GST-tagged

• Cat.No.: FRS3-1449H
• Product Overview: Recombinant full-length human FRS3 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 87 kDa.

Specification

• Cat. No.: FRS3-1449H
• Description: FRS3 or fibroblast growth factor receptor substrate 3 is a peripheral plasma membrane protein that is a substrate for the fibroblast growth factor receptor. During FGF or NGF stimulation, FRS3 becomes tyrosine phosphorylated and then serves as a platform for the recruitment of multiple signaling proteins for activation of the Ras-MAP kinase signaling cascade. FRS3 is mainly expressed in fibroblast and myoblast cell lines and undergo robust tyrosine phosphorylation in response to several mitogenic ligands. Through interaction with Rho family of small GTPases, FRS3 has been implicated in the reorganization of the actin cytoskeleton and subsequent morphological changes in various cells.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: FRS3 fibroblast growth factor receptor substrate 3 [ Homo sapiens ]
• Synonyms: FRS3; fibroblast growth factor receptor substrate 3; SNT2; FRS2B; SNT-2; FRS2beta; MGC17167; FRS2-beta; FGFR substrate 3; OTTHUMP00000016383; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor); OTTHUMP00000039786; FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2
• Gene ID: 10817
• mRNA Refseq: NM_006653
• Protein Refseq: NP_006644
• MIM: 607744
• UniProt ID: O43559
• Chromosome Location: 6p21.1
• Function: fibroblast growth factor receptor binding; insulin receptor binding

Reviews

01/13/2022

The FRS3 protein not only fulfills my experimental requirements but is also backed by excellent technical support, which guarantees a smooth and successful research experience.

07/15/2017

The manufacturer of the FRS3 protein plays a vital role in supporting my trials.

04/26/2017

By using the FRS3 protein in my experiments, I am confident in obtaining accurate and dependable data.

Q&As

How does FRS3 participate in immune system regulation, and what clinical applications does this have?

FRS3 is involved in immune response modulation, and understanding its function may lead to the development of immunotherapies or treatments for autoimmune disorders.

What clinical applications are associated with understanding FRS3's involvement in cancer?

Targeting FRS3 may provide a novel approach for cancer therapy, and assessing its levels could serve as a diagnostic and prognostic marker.

How does FRS3 protein contribute to neurological disorders, and what clinical implications does this have

FRS3 has been implicated in certain neurological disorders, and understanding its role may open avenues for therapeutic interventions in neurodegenerative diseases.

How is FRS3 protein implicated in cancer development?

FRS3 has been found to be overexpressed in certain cancers, suggesting a potential role in promoting tumor growth and progression.

Are there any ongoing clinical trials investigating FRS3 as a therapeutic target for cancer treatment?

Research is underway to explore the efficacy of FRS3-targeted therapies in clinical trials, evaluating its potential in cancer patients.