Recombinant Human FSHR protein(18-366aa), His-Trx-tagged

• Cat.No.: FSHR-1316H
• Product Overview: Recombinant Human FSHR protein(P23945)(18-366aa), fused with N-terminal His and Trx tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: N-His-Trx
• Protein length: 18-366aa
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 58.1 kDa
• AASequence: CHHRICHCSNRVFLCQESKVTEIPS DLPRNAIELRFVLTKLRVIQKGAFS GFGDLEKIEISQNDVLEVIEADVFS NLPKLHEIRIEKANNLLYINPEAFQ NLPNLQYLLISNTGIKHLPDVHKIH SLQKVLLDIQDNINIHTIERNSFVG LSFESVILWLNKNGIQEIHNCAFNG TQLDELNLSDNNNLEELPNDVFHGA SGPVILDISRTRIHSLPSYGLENLK KLRARSTYNLKKLPTLEKLVALMEA SLTYPSHCCAFANWRRQISELHPIC NKSILRQEVDYMTQARGQRSSLAED NESSYSRGFDMTYTEFDYDLCNEVV DVTCSPKPDAFNPCEDIMGYNILR
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Gene Information

• Gene Name: FSHR follicle stimulating hormone receptor [ Homo sapiens ]
• Official Symbol: FSHR
• Synonyms: FSHR; follicle stimulating hormone receptor; ODG1; follicle-stimulating hormone receptor; FSHRO; LGR1; FSH receptor; follitropin receptor; MGC141667; MGC141668
• Gene ID: 2492
• mRNA Refseq: NM_000145
• Protein Refseq: NP_000136
• MIM: 136435
• UniProt ID: P23945

Reviews

05/16/2021

Exceptional protein expression optimization support, highly appreciated assistance.

02/11/2021

Accurate protein structural analysis, indispensable for our investigations.

10/05/2020

Timely antibody validation, an invaluable asset for our laboratory.

Q&As

What are the mechanisms by which FSHR modulates bone density and the risk of osteoporosis?

FSHR regulates bone density, with implications for osteoporosis risk, particularly post-menopause.

How do alterations in FSHR expression or signaling affect hormone replacement therapies?

Changes in FSHR signaling can influence the efficacy and outcomes of hormone replacement therapies.

How does FSHR (Follicle Stimulating Hormone Receptor) regulate ovarian follicle development and ovulation in females?

FSHR is key in stimulating ovarian follicle growth and triggering ovulation in women.

What role does FSHR play in spermatogenesis and male fertility?

FSHR plays a significant role in male fertility, essential for the process of spermatogenesis.

What is the impact of FSHR mutations on fertility and the development of reproductive disorders?

Mutations in FSHR can lead to fertility issues and reproductive disorders in both sexes.

How does FSHR influence hormonal regulation and menstrual cycle in women?

FSHR affects hormonal balance and menstrual cycle regulation in females.

How does FSHR contribute to the pathogenesis of polycystic ovary syndrome (PCOS)?

FSHR is involved in PCOS pathogenesis, potentially affecting ovarian function and hormone levels.