Recombinant Human GABRB3 Protein (M1-F332, A447-N473 end), twin-StrepII tagged

• Cat.No.: GABRB3-0625H
• Product Overview: Recombinant Human GABRB3(M1-F332)-(SQPARAA)-(A447-N473 end)-twin-StrepII Protein was expressed in Mammalian cell.

Specification

• Description: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity. The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. Plays an important role in somatosensation and in the production of antinociception.
• Source: Mammalian cell
• Species: Human
• Tag: twin-StrepII
• Form: Liquid
• Protein Length: M1-F332, A447-N473 end
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 80%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.005% (w/v) GDN, 0.0005% (w/v) CHS
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 [ Homo sapiens (human) ]
• Official Symbol: GABRB3
• Synonyms: GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid receptor subunit beta-3; GABA(A) receptor; beta 3; GABA(A) receptor, beta 3; GABAA receptor beta-3 subunit; GABA(A) receptor beta-3 subunit; GABA-alpha receptor beta-2 subunit; ECA5; MGC9051
• Gene ID: 2562
• mRNA Refseq: NM_000814
• Protein Refseq: NP_000805
• UniProt ID: P28472