Recombinant Human GABRD Protein, His-tagged

• Cat.No.: GABRD-1551H
• Product Overview: Recombinant Human GABRD Protein (Gly21-Gly193) with N-His tag was expressed in E. coli.

Specification

• Description: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 23.2 kDa
  Accurate Molecular Mass: 23 kDa
• Protein length: Gly21-Gly193
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: GABRD gamma-aminobutyric acid (GABA) A receptor, delta [ Homo sapiens (human) ]
• Official Symbol: GABRD
• Synonyms: GABRD; gamma-aminobutyric acid (GABA) A receptor, delta; gamma-aminobutyric acid receptor subunit delta; GABA(A) receptor; delta; GABA(A) receptor, delta; GABA(A) receptor subunit delta; GABA-A receptor, delta polypeptide; EJM7; EIG10; GEFSP5; MGC45284
• Gene ID: 2563
• mRNA Refseq: NM_000815
• Protein Refseq: NP_000806
• MIM: 137163
• UniProt ID: O14764