| Description : |
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
N-His |
| Form : |
Lyophilized |
| Molecular Mass : |
67.5 kDa |
| AA Sequence : |
MGSSHHHHHHSSGLVPRGSHMASPG SGFWSFGSEDGSGDSENPGTARAWC QVAQKFTGGIGNKLCALLYGDAEKP AESGGSQPPRAAARKAACACDQKPC SCSKVDVNYAFLHATDLLPACDGER PTLAFLQDVMNILLQYVVKSFDRST KVIDFHYPNELLQEYNWELADQPQN LEEILMHCQTTLKYAIKTGHPRYFN QLSTGLDMVGLAADWLTSTANTNMF TYEIAPVFVLLEYVTLKKMREIIGW PGGSGDGIFSPGGAISNMYAMMIAR FKMFPEVKEKGMAALPRLIAFTSEH SHFSLKKGAAALGIGTDSVILIKCD ERGKMIPSDLERRILEAKQKGFVPF LVSATAGTTVYGAFDPLLAVADICK KYKIWMHVDAAWGGGLLMSRKHKWK LSGVERANSVTWNPHKMMGVPLQCS ALLVREEGLMQNCNQMHASYLFQQD KHYDLSYDTGDKALQCGRHVDVFKL WLMWRAKGTTGFEAHVDKCLELAEY LYNIIKNREGYEMVFDGKPQHTNVC FWYIPPSLRTLEDNEERMSRLSKVA PVIKARMMEYGTTMVSYQPLGDKVN FFRMVISNPAATHQDIDFLIEEIER LGQDL |
| Purity : |
90% |
| Storage : |
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : |
Lyophilized from sterile PBS, pH 8.0, 5% trehalose, 5% mannitol. |
