Recombinant Human GCSH, His-tagged
Cat.No. : | GCSH-27469TH |
Product Overview : | Recombinant full length Human GCSH with N terminal His tag; 149 amino acids with tag, Predicted MWt 16.4 kDa. |
- Specification
- Gene Information
- Related Products
Description : | Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome. |
Protein length : | 125 amino acids |
Conjugation : | HIS |
Molecular Weight : | 16.400kDa inclusive of tags |
Source : | E. coli |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | pH: 8.00Constituents:0.32% Tris HCl, 10% Glycerol, 0.02% DTT, 0.88% Sodium chloride |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMGSMS VRKFTEKHEWVTTENGIGTVGISNF AQEALGDVVYCSLPEVGTKLNKQDE FGALESVKAASELYSPLSGEVTEIN EALAENPGLVNKSCYEDGWLIKMTL SNPSELDELMSEEAYEKYIKSIEE |
Sequence Similarities : | Belongs to the gcvH family.Contains 1 lipoyl-binding domain. |
Gene Name : | GCSH glycine cleavage system protein H (aminomethyl carrier) [ Homo sapiens ] |
Official Symbol : | GCSH |
Synonyms : | GCSH; glycine cleavage system protein H (aminomethyl carrier); glycine cleavage system H protein, mitochondrial; lipoic acid containing protein; |
Gene ID : | 2653 |
mRNA Refseq : | NM_004483 |
Protein Refseq : | NP_004474 |
MIM : | 238330 |
Uniprot ID : | P23434 |
Chromosome Location : | 16q23.2 |
Function : | aminomethyltransferase activity; enzyme binding; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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