Recombinant Human GFRA1 Protein, C-Fc-tagged

• Cat.No.: GFRA1-01H
• Product Overview: Recombinant Human GDNF Receptor alpha 1 is produced by our Mammalian expression system and the target gene encoding Asp25-Lys429 is expressed with a Fc tag at the C-terminus.

Specification

• Description: This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
• Source: Human Cells
• Species: Human
• Tag: Fc
• Molecular Mass: Predicted Molecular: 72.3 kDa
  AP Molecular Weight: 85 kDa, reducing conditions.
• Protein Length: Asp25-Lys429
• Endotoxin: Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
• Quality Control Test: Greater than 95% as determined by reducing SDS-PAGE.
• Notes: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
• Storage: Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
• Storage Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
• Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
  Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Shipping: The product is shipped at ambient temperature.

Gene Information

• Gene Name: GFRA1 GDNF family receptor alpha 1 [ Homo sapiens (human) ]
• Official Symbol: GFRA1
• Synonyms: GFRA1; GDNF family receptor alpha 1; GDNFR; RET1L; RETL1; RHDA4; TRNR1; GDNFRA; GFRalpha-1; GFR-ALPHA-1; GDNFR-alpha-1; GDNF family receptor alpha-1; GDNF receptor alpha 1d; GDNF receptor alpha 1e; GPI-linked anchor protein; Glial cell line-derived neurotrophic factor receptor alpha; PI-linked cell-surface accessory protein; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
• Gene ID: 2674
• mRNA Refseq: NM_145793
• Protein Refseq: NP_665736
• MIM: 601496
• UniProt ID: P56159