| Description : |
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
47.6 kDa |
| Protein Length : |
464 |
| AA Sequence : |
MILANVFCLFFFLDETLRSLASPSS LQGPELHGWRPPVDCVRANELCAAE SNCSSRYRTLRQCLAGRDRNTMLAN KECQAALEVLQESPLYDCRCKRGMK KELQCLQIYWSIHLGLTEGEEFYEA SPYEPVTSRLSDIFRLASIFSGTGA DPVVSAKSNHCLDAAKACNLNDNCK KLRSSYISICNREISPTERCNRRKC HKALRQFFDRVPSEYTYRMLFCSCQ DQACAERRRQTILPSCSYEDKEKPN CLDLRGVCRTDHLCRSRLADFHANC RASYQTVTSCPADNYQACLGSYAGM IGFDMTPNYVDSSPTGIVVSPWCSC RGSGNMEEECEKFLRDFTENPCLRN AIQAFGNGTDVNVSPKGPSFQATQA PRVEKTPSLPDDLSDSTSLGTSVIT TCTSVQEQGLKANNSKELSMCFTEL TTNIIPGSNKVIKPNSGPSRARPSA ALTVLSVLMLKLAL |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
