| Description : |
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
78.1 kDa |
| AA Sequence : |
MAEAEGESLESWLNKATNPSNRQED WEYIIGFCDQINKELEGPQIAVRLL AHKIQSPQEWEALQALTVLEACMKN CGRRFHNEVGKFRFLNELIKVVSPK YLGDRVSEKVKTKVIELLYSWTMAL PEEAKIKDAYHMLKRQGIVQSDPPI PVDRTLIPSPPPRPKNPVFDDEEKS KLLAKLLKSKNPDDLQEANKLIKSM VKEDEARIQKVTKRLHTLEEVNNNV RLLSEMLLHYSQEDSSDGDRELMKE LFDQCENKRRTLFKLASETEDNDNS LGDILQASDNLSRVINSYKTIIEGQ VINGEVATLTLPDSEGNSQCSNQGT LIDLAELDTTNSLSSVLAPAPTPPS SGIPILPPPPQASGPPRSRSSSQAE ATLGPSSTSNALSWLDEELLCLGLA DPAPNVPPKESAGNSQWHLLQREQS DLDFFSPRPGTAACGASDAPLLQPS APSSSSSQAPLPPPFPAPVVPASVP APSAGSSLFSTGVAPALAPKVEPAV PGHHGLALGNSALHHLDALDQLLEE AKVTSGLVKPTTSPLIPTTTPARPL LPFSTGPGSPLFQPLSFQSQGSPPK GPELSLASIHVPLESIKPSSALPVT AYDKNGFRILFHFAKECPPGRPDVL VVVVSMLNTAPLPVKSIVLQAAVPK SMKVKLQPPSGTELSPFSPIQPPAA ITQVMLLANPLKEKVRLRYKLTFAL GEQLSTEVGEVDQFPPVEQWGNLTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
