| Description : |
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
54.3 kDa |
| Protein Length : |
638 |
| AA Sequence : |
MDLWQLLLTLALAGSSDAFSGSEAT AAILSRAPWSLQSVNPGLKTNSSKE PKFTKCRSPERETFSCHWTDEVHHG TKNLGPIQLFYTRRNTQEWTQEWKE CPDYVSAGENSCYFNSSFTSIWIPY CIKLTSNGGTVDEKCFSVDEIVQPD PPIALNWTLLNVSLTGIHADIQVRW EAPRNADIQKGWMVLEYELQYKEVN ETKWKMMDPILTTSVPVYSLKVDKE YEVRVRSKQRNSGNYGEFSEVLYVT LPQMSQFTCEEDFYFPWLLIIIFGI FGLTVMLFVFLFSKQQRIKMLILPP VPVPKIKGIDPDLLKEGKLEEVNTI LAIHDSYKPEFHSDDSWVEFIELDI DEPDEKTEESDTDRLLSSDHEKSHS NLGVKDGDSGRTSCCEPDILETDFN ANDIHEGTSEVAQPQRLKGEADLLC LDQKNQNNSPYHDACPATQQPSVIQ AEKNKPQPLPTEGAESTHQAAHIQL SNPSSLSNIDFYAQVSDITPAGSVV LSPGQKNKAGMSQCDMHPEMVSLCQ ENFLMDNAYFCEADAKKCIPVAPHI KVESHIQPSLNQEDIYITTESLTTA AGRPGTGEHVPGSEMPVPDYTSIHI VQSPQGLILNATALPLPDKEFLSSC GYVSTDQLNKIMP |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
