Recombinant Human GIF, His-tagged
Cat.No. : | GIF-1288H |
Product Overview : | Recombinant Human GIF, a glycosylated, polypeptide chain fussed with hexa-histidine tag at C-terminal was expressed in Sf9 Insect Cells. |
- Specification
- Gene Information
- Related Products
Description : | Intrinsic Factor is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12 in the terminal ileum. Vitamin B12 is essential for erythrocyte maturation and mutations in the Intrinsic Factor may lead to congenital pernicious anemia. Upon entry into the stomach, vitamin B12 binds to one of two B12 binding proteins present in the gastric fluid. In the less acidic environment of the small intestine, these proteins dissociate from the vitamin, allowing it to bind to intrinsic factor and enter the portal circulation through a receptor in the ileal mucosa specific for the B12-intrinsic factor complex. |
Source : | Sf9 Insect Cells |
Species : | Human |
Tag : | His |
Form : | The protein solution (0.7mg/ml) contains 20mM HEPES pH-8, 100mM NaCl, 20% Glycerol. |
Molecular Mass : | 55,000 Dalton |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Stability : | Store at 4 centigrade if entire vial will be used within 2-4 weeks. Store, frozen at -20 centigrade for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
Gene Name : | GIF gastric intrinsic factor (vitamin B synthesis) [ Homo sapiens ] |
Official Symbol : | GIF |
Synonyms : | IF; INF; IFMH; TCN3; gastric intrinsic factor; intrinsic factor |
Gene ID : | 2694 |
mRNA Refseq : | NM_005142 |
Protein Refseq : | NP_005133 |
MIM : | 609342 |
UniProt ID : | P27352 |
Chromosome Location : | 11q13 |
Pathway : | Cobalamin (Cbl, vitamin B12) transport and metabolism, organism-specific biosystem; Defective AMN causes hereditary megaloblastic anemia 1, organism-specific biosystem; Defects in cobalamin (B12) metabolism, organism-specific biosystem |
Function : | cobalamin binding |
Products Types
◆ Recombinant Protein | ||
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GIF-3552M | Recombinant Mouse GIF Protein, His (Fc)-Avi-tagged | +Inquiry |
GIF-2189R | Recombinant Rat GIF Protein, His (Fc)-Avi-tagged | +Inquiry |
GIF-3299H | Recombinant Human GIF protein(Met1-Tyr417), His-tagged | +Inquiry |
GIF-121H | Recombinant Human GIF Protein (Met1-Tyr417), C-His tagged, Animal-free, Carrier-free | +Inquiry |
◆ Lysates | ||
GIF-1247HCL | Recombinant Human GIF cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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