Recombinant Human GLIS3 Protein, GST-tagged

• Cat.No.: GLIS3-4964H
• Product Overview: Human GLIS3 full-length ORF ( ABZ92210.1, 1 a.a. - 774 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 85.2 kDa
• AA Sequence: MVQRLGLISPPASQVSTACNQISPS LQRAMNAANLNIPPSDTRSLISRES LASTTLSLTESQSASSMKQEWSQGY RALPSLSNHGSQNGLDLGDLLSLPP GTSMSSNSVSNSLPSYLFGTESSHS PYPSPRHSSTRSHSARSKKRALSLS PLSDGIGIDFNTIIRTSPTSLVAYI NGSRASPANLSPQPEVYGHFLGVRG SCIPQPRPVPGSQKGVLVAPGGLAL PAYGEDGALEHERMQQLEHGGLQPG LVNHMVVQHGLPGPDSQPAGLFKTE RLEEFPGSTVDLPPAPPLPPLPPPQ GPPPPYHAHAHLHHPELGPHAQQLA LPQATLDDDGEMDGIGGKHCYRWID CSALYDQQEELVRHIEKVHIDQRKG EDFTCFWAGCPRRYKPFNARYKLLI HMRVHSGEKPNKCTFEGCEKAFSRL ENLKIHLRSHTGEKPYLCQHPGCQK AFSNSSDRAKHQRTHLDTKPYACQI PGCTKRYTDPSSLRKHVKAHSSKEQ QARKKLRSSTEVHPDLLTDCLTVQS LQPATSPRDAAAEGTVGRSPGPGPD LYSAPIFSSNYSSRSGTAAGAVPPP HPVSHPSPGHNVQGSPHNPSSQLPP LTAVDAGAERFAPSAPSPHHISPRR VPAPSSILQRTQPPYTQQPSGSHLK SYQPETNSSFQPNGIHVHGFYGQLQ KFCPPHYPDSQRIVPPVSSCSVVPS FEDCLVPTSMGQASFDVFHRAFSTH SGITVYDLPSSSSSLFGESLRSGAE DATFLQISTVDRCPSQLSSVYTEG
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GLIS3 GLIS family zinc finger 3 [ Homo sapiens ]
• Official Symbol: GLIS3
• Synonyms: GLIS3; GLIS family zinc finger 3; zinc finger protein 515, ZNF515; zinc finger protein GLIS3; MGC33662; OK/KNS-cl.4; GLI-similar 3; zinc finger protein 515; ZNF515; FLJ38999; FLJ90578
• Gene ID: 169792
• mRNA Refseq: NM_001042413
• Protein Refseq: NP_001035878
• MIM: 610192
• UniProt ID: Q8NEA6