Recombinant Human GP1BA 293 Cell Lysate
Cat.No. : | GP1BA-5823HCL |
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Description : | Antigen standard for glycoprotein Ib (platelet), alpha polypeptide (GP1BA) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
Source : | HEK 293 cells |
Species : | Human |
Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
Size : | 0.1 mg |
Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
Gene Name : | GP1BA glycoprotein Ib (platelet), alpha polypeptide [ Homo sapiens ] |
Official Symbol : | GP1BA |
Synonyms : | GP1BA; glycoprotein Ib (platelet), alpha polypeptide; GP1B; platelet glycoprotein Ib alpha chain; CD42b; GP-Ib alpha; antigen CD42b-alpha; platelet membrane glycoprotein 1b-alpha subunit; BSS; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; CD42b-alpha; MGC34595; |
Gene ID : | 2811 |
mRNA Refseq : | NM_000173 |
Protein Refseq : | NP_000164 |
MIM : | 606672 |
UniProt ID : | P07359 |
Chromosome Location : | 17pter-p12 |
Pathway : | ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; GP1b-IX-V activation signalling, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Hemostasis, organism-specific biosystem; |
Function : | protein binding; thrombin receptor activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGlycoprotein Ib platelet subunit alpha (GP1BA) plays a crucial role in platelet physiology and hemostasis, specifically in platelet adhesion.
Dysregulation or abnormal expression of GP1BA is associated with conditions such as Bernard-Soulier syndrome and other platelet disorders.
GP1BA contributes to platelet adhesion by interacting with von Willebrand factor (vWF), facilitating platelet plug formation at vascular injury sites.
Interactions or binding partners of GP1BA include vWF and other components of the platelet glycoprotein Ib-IX-V complex, influencing platelet function.
GP1BA participates in the regulation of blood clotting and coagulation cascades by initiating platelet activation and aggregation.
GP1BA is predominantly localized on the surface of platelets, especially within the platelet membrane.
There are potential therapeutic implications related to GP1BA in diseases involving platelet disorders, making it a target for drug development.
Customer Reviews (3)
Write a reviewIts compatibility with collaborative platforms and open-source tools facilitated sharing and reproducibility of our experiments.
The product's support in the form of educational resources positively impacted the learning curve for our researchers.
The product's track record of being featured in influential publications positively influenced our decision to use it.
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