Recombinant Human GPR149 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | GPR149-5553H |
Product Overview : | GPR149 MS Standard C13 and N15-labeled recombinant protein (NP_001033794) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 80.8 kDa |
AA Sequence : | MSLFLSNLSTNDSSLWKENHNSTDL LNPPGTLNIYLFCLTCLMTFAALVG SIYSLISLLKMQNRTVVSMLVASWS VDDLMSVLSVTIFMFLQWPNEVPGY FQFLCTTSALMYLCQGLSSNLKATL LVSYNFYTMHRGVGSQTASRRSGQV LGVVLTVWAASLLLSALPLCGWGAF VRTPWGCLVDCSSSYVLFLSIVYAL AFGLLVGLSVPLTHRLLCSEEPPRL HSNYQEISRGASIPGTPPTAGRVVS LSPEDAPGPSLRRSGGCSPSSDTVF GPGAPAAAGAEACRRENRGTLYGTR SFTVSVAQKRFALILALTKVVLWLP MMMHMVVQNVVGFQSLPLETFSFLL TLLATTVTPVFVLSKRWTHLPCGCI INCRQNAYAVASDGKKIKRKGFEFN LSFQKSYGIYKIAHEDYYDDDENSI FYHNLMNSECETTKDPQRDNRNIFN AIKVEISTTPSLDSSTQRGINKCTN TDITEAKQDSNNKKDAFSDKTGGDI NYEETTFSEGPERRLSHEESQKPDL SDWEWCRSKSERTPRQRSGYALAIP LCAFQGTVSLHAPTGKTLSLSTYEV SAEGQKITPASKKIEVYRSKSVGHE PNSEDSSSTFVDTSVKIHLEVLEIC DNEEALDTVSIISNISQSSTQVRSP SLRYSRKENRFVSCDLGETASYSLF LPTSNPDGDINISIPDTVEAHRQNS KRQHQERDGYQEEIQLLNKAYRKRE EESKGSTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | GPR149 G protein-coupled receptor 149 [ Homo sapiens (human) ] |
Official Symbol : | GPR149 |
Synonyms : | GPR149; G protein-coupled receptor 149; probable G-protein coupled receptor 149; IEDA; PGR10; G protein-coupled receptor PGR10; G-protein coupled receptor PGR10; |
Gene ID : | 344758 |
mRNA Refseq : | NM_001038705 |
Protein Refseq : | NP_001033794 |
UniProt ID : | Q86SP6 |
Products Types
◆ Recombinant Protein | ||
GPR149-2240H | Recombinant Human GPR149 Protein, MYC/DDK-tagged | +Inquiry |
GPR149-3855M | Recombinant Mouse GPR149 Protein, His (Fc)-Avi-tagged | +Inquiry |
Gpr149-3291M | Recombinant Mouse Gpr149 Protein, Myc/DDK-tagged | +Inquiry |
GPR149-2306R | Recombinant Rat GPR149 Protein, His (Fc)-Avi-tagged | +Inquiry |
GPR149-6228C | Recombinant Chicken GPR149 | +Inquiry |
◆ Assay kits | ||
Kit-1290 | GPR149 CHO-K1 β-Arrestin Orphan GPCR Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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