Recombinant Human GPX4 Protein, His-tagged
Cat.No. : | GPX4-22H |
Product Overview : | Recombinant Human GPX4 Protein, fused to His-tag, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Supplied as a 0.2 μm filtered solution in 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.0) added with 300mM Imidazole and 0.7% Sarcosyl, 15% glycerol. |
Molecular Mass : | ~37.3 KDa |
AA Sequence : | MFFTKALEHRVAAVCLTLDPEVVCR VMEYCSRELILSKPILNAVAETFVC QTEKFSPRQISALMEPFGKLNYLPP NASALFRKLENVLFTHFNYFPPKSL LKLLHSCSLNECHPVNFLAKIFKPL FLQRLQGKESHLDTLSRAQLTQLFL ASVLECPFYKGPKLLPKYQVKSFLT PCCSLETPVDSQLYRYVKIGLTNLL GARLYFAPKVLTPYCYTIDVEIKLD EEGFVLPSTANEDIHKRIALCIDGP KRFCSNSKHLLGKEAIKQRHLQLLG YQVVQIPYHEIGMLKSRRELVEYLQ RKLFSQNTVHWLQELEHHHHHH |
Purity : | >90% |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 0.4 mg/mL |
Gene Name : | GPX4 glutathione peroxidase 4 [ Homo sapiens (human) ] |
Official Symbol : | GPX4 |
Synonyms : | MCSP; SMDS; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx |
Gene ID : | 2879 |
mRNA Refseq : | NM_002085 |
Protein Refseq : | NP_002076 |
MIM : | 138322 |
UniProt ID : | P36969 |
Products Types
◆ Recombinant Protein | ||
GPX4-29080TH | Recombinant Human GPX4 Protein | +Inquiry |
GPX4-1894H | Recombinant Human GPX4 Protein, N-His-tagged | +Inquiry |
GPX4-2333R | Recombinant Rat GPX4 Protein, His (Fc)-Avi-tagged | +Inquiry |
GPX4-1895H | Recombinant Human GPX4 Protein, Flag-tagged | +Inquiry |
GPX4-027H | Recombinant Human GPX4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GPX4-308HCL | Recombinant Human GPX4 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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