Recombinant Human Grancalcin, EF-hand Calcium Binding Protein, His-tagged
Cat.No. : | GCA-6903H |
Product Overview : | Recombinant human GCA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 26.1 kDa. |
- Specification
- Gene Information
- Related Products
Description : | GCA, also known as Grancalcin, is calcium-binding protein that is especially abundant in human neutrophils. It belongs to the penta EF-hand (PEF) subfamily of EF-hand proteins, which also comprises calpain, sorcin, peflin, and ALG-2. This protein undergoes important conformational changes upon binding of calcium, which subsequently exposes hydrophobic amino acid residues, which direct the protein to hydrophobic surfaces. It interacts with L-plastin, a protein known to have actin bundling activity, which suggests that GCA may play a role in the regulation of neutrophils adhesion. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl. |
Molecular Mass : | 26.1 kDa (237aa), confirmed by MALDI-TOF |
Protein length : | 1-217aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MAYPGYGGGF GNFS IQVPGM QMGQPVPETG PAILLDGYSG PAYSDTYSSA GDSVYTYFSA VAGQDGEVDA EELQRCLTQS GINGTYSPFS LETCRIMIAM LDRDHTGKMG FNAFKELWAA LNAWKENFMT VDQDGSGTVE HHELRQAIGL MGYRLSPQTL TTIVKRYSKN GRIFFDDYVA CCVKLRALTD FFRKRDHLQQ GSANFIYDDF LQGTMAI |
Purity : | >95% by SDS-PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles. |
Concentration : | 1.0 mg/ml (determined by Bradford assay) |
Gene Name : | GCA grancalcin, EF-hand calcium binding protein [ Homo sapiens ] |
Official Symbol : | GCA |
Synonyms : | GCA; grancalcin, EF-hand calcium binding protein; grancalcin, EF hand calcium binding protein; grancalcin; GCL; grancalcin, penta-EF-hand protein; grancalcin, EF-hand calcium-binding protein; |
Gene ID : | 25801 |
mRNA Refseq : | NM_012198 |
Protein Refseq : | NP_036330 |
MIM : | 607030 |
UniProt ID : | P28676 |
Chromosome Location : | 2p14-q14.3 |
Function : | calcium ion binding; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
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GCA-4787H | Recombinant Human GCA Protein, GST-tagged | +Inquiry |
GCA-1316H | Recombinant Human GCA Protein | +Inquiry |
GCA-1819R | Recombinant Rhesus monkey GCA Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
GCA-2H | Native Human Gastrointestinal Cancer Antigen | +Inquiry |
◆ Lysates | ||
GCA-5994HCL | Recombinant Human GCA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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