Recombinant Human GREM1 Protein (Lys26-Asp184), His tagged
Cat.No. : | GREM1-2879H |
Product Overview : | Recombinant human GREM1 (Lys26-Asp184) protein fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | GREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as inhibitor of monocyte chemotaxis. GREM1 is highly expressed in small intestine, fetal brain and colon. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 19.41 kDa |
Protein Length : | Lys26-Asp184 |
Purity : | >90 % as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | GREM1 gremlin 1 [ Homo sapiens (human) ] |
Official Symbol : | GREM1 |
Synonyms : | GREM1; gremlin 1; CKTSF1B1, cysteine knot superfamily 1, BMP antagonist 1, gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis); gremlin-1; DAND2; DRM; gremlin; gremlin 1-like protein; DAN domain family member 2; increased in high glucose-2; proliferation-inducing gene 2; increased in high glucose protein 2; cell proliferation-inducing gene 2 protein; cysteine knot superfamily 1, BMP antagonist 1; gremlin 1, cysteine knot superfamily, homolog; down-regulated in Mos-transformed cells protein; PIG2; IHG-2; GREMLIN; CKTSF1B1; MGC126660; |
Gene ID : | 26585 |
mRNA Refseq : | NM_001191322 |
Protein Refseq : | NP_001178251 |
MIM : | 603054 |
UniProt ID : | O60565 |
Products Types
◆ Recombinant Protein | ||
GREM1-2214H | Recombinant Human GREM1 Protein, His-tagged | +Inquiry |
GREM1-5321H | Recombinant Human GREM1 Protein, GST-tagged | +Inquiry |
GREM1-494H | Recombinant Human GREM1 Protein | +Inquiry |
Grem1-315M | Recombinant Mouse Grem1 Protein, His-tagged | +Inquiry |
GREM1-312C | Recombinant Chicken GREM1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GREM1-001MCL | Recombinant Mouse GREM1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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