Recombinant Human GRIN1 protein, His&Myc-tagged

• Cat.No.: GRIN1-2995H
• Product Overview: Recombinant Human GRIN1 protein(Q05586)(19-559aa), fused to N-terminal His tag and C-terminal Myc tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His&Myc
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 68.0 kDa
• Protein length: 19-559aa
• AA Sequence: RAACDPKIVNIGAVLSTRKHEQMFR EAVNQANKRHGSWKIQLNATSVTHK PNAIQMALSVCEDLISSQVYAILVS HPPTPNDHFTPTPVSYTAGFYRIPV LGLTTRMSIYSDKSIHLSFLRTVPP YSHQSSVWFEMMRVYSWNHIILLVS DDHEGRAAQKRLETLLEERESKAEK VLQFDPGTKNVTALLMEAKELEARV IILSASEDDAATVYRAAAMLNMTGS GYVWLVGEREISGNALRYAPDGILG LQLINGKNESAHISDAVGVVAQAVH ELLEKENITDPPRGCVGNTNIWKTG PLFKRVLMSSKYADGVTGRVEFNED GDRKFANYSIMNLQNRKLVQVGIYN GTHVIPNDRKIIWPGGETEKPRGYQ MSTRLKIVTIHQEPFVYVKPTLSDG TCKEEFTVNGDPVKKVICTGPNDTS PGSPRHTVPQCCYGFCIDLLIKLAR TMNFTYEVHLVADGKFGTQERVNNS NKKEWNGMMGELLSGQADMIVAPLT INNERAQYIEFSKPFKYQGLTILVK KEIPRSTLDSFMQPFQ
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 [ Homo sapiens ]
• Official Symbol: GRIN1
• Synonyms: GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDAR1; glutamate [NMDA] receptor subunit zeta-1; GluN1; NMD-R1; glutamate [NMDA] receptor subunit zeta 1; N-methyl-D-aspartate receptor subunit NR1; N-methyl-D-aspartate receptor channel, subunit zeta-1; NR1; MRD8; NMDA1
• Gene ID: 2902
• mRNA Refseq: NM_000832
• Protein Refseq: NP_000823
• MIM: 138249
• UniProt ID: Q05586

Reviews

02/25/2022

This strong track record of excellence further attests to the GRIN1 protein's capability to meet the rigorous demands of research projects.

12/02/2019

Whether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.

07/01/2016

Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.

Q&As

How is the GRIN1 protein involved in neurodegenerative diseases?

Dysregulation of the NMDA receptor, due to GRIN1 mutations, has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's.

What neurological disorders are associated with GRIN1 mutations?

Disorders such as epilepsy, autism spectrum disorders, and schizophrenia have been linked to GRIN1 mutations.

Is there a genetic test for GRIN1 mutations?

Yes, genetic testing can identify mutations in the GRIN1 gene, which may be helpful in diagnosing certain neurological conditions.

How does the GRIN1 protein contribute to synaptic plasticity?

The NMDA receptor, with GRIN1 as a subunit, is crucial for long-term potentiation, a process underlying memory formation and learning.

Can variations in the GRIN1 gene affect response to antidepressants?

Some studies suggest that genetic variations in GRIN1 may influence an individual's response to antidepressant medications.