Recombinant Human GRN Protein, MYC/DDK-tagged

• Cat.No.: GRN-2358H
• Product Overview: Recombinant human GRN protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Description: Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. [UniProtKB/Swiss-Prot Function]
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 61.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: GRN granulin [ Homo sapiens ]
• Official Symbol: GRN
• Synonyms: CLN11; GEP; GP88; PCDGF; PEPI; PGRN
• Gene ID: 2896
• mRNA Refseq: NM_002087
• Protein Refseq: NP_002078
• MIM: 138945
• UniProt ID: P28799

Reviews

06/16/2022

The outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.

04/30/2022

Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.

06/29/2019

This protein has a short half-life, high clearance rate, and high safety and efficacy.

Q&As

Are there have any relationship between GRN protein and TDP-43 protein?

There is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.

Why does GRN protein play a role in neuroprotection?

GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.

What is the diagnostic significance of GRN protein in neurodegenerative diseases?

Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.

What is the role of GRN protein in Alzheimer's disease?

The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.

Are there transcription factors involved in the regulation of GRN protein expression?

Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.

Which role of GRN protein in prefrontal dementia?

GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.