Recombinant Human GTF2B, GST-tagged
Cat.No. : | GTF2B-13590H |
Product Overview : | Recombinant Human GTF2B protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named lurcher, in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-316a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | GTF2B general transcription factor IIB [ Homo sapiens ] |
Official Symbol : | GTF2B |
Synonyms : | GTF2B; general transcription factor IIB; transcription initiation factor IIB; TFIIB; S300-II; general transcription factor TFIIB; RNA polymerase II transcription factor IIB; TF2B; |
Gene ID : | 2959 |
mRNA Refseq : | NM_001514 |
Protein Refseq : | NP_001505 |
MIM : | 189963 |
UniProt ID : | Q00403 |
Chromosome Location : | 1p22-p21 |
Pathway : | Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Disease, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Gene Expression, organism-specific biosystem; HIV Infection, organism-specific biosystem; HIV Life Cycle, organism-specific biosystem; |
Function : | DNA binding; metal ion binding; protein binding; thyroid hormone receptor binding; transcription factor binding; translation initiation factor activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
GTF2B-4440H | Recombinant Human GTF2B Protein, GST-tagged | +Inquiry |
GTF2B-2395R | Recombinant Rat GTF2B Protein, His (Fc)-Avi-tagged | +Inquiry |
GTF2B-1823R | Recombinant Rhesus Macaque GTF2B Protein, His (Fc)-Avi-tagged | +Inquiry |
GTF2B-3988M | Recombinant Mouse GTF2B Protein, His (Fc)-Avi-tagged | +Inquiry |
Gtf2b-3323M | Recombinant Mouse Gtf2b Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
GTF2B-5703HCL | Recombinant Human GTF2B 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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