| Description : |
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
32.6 kDa |
| AA Sequence : |
MERRLGVRAWVKENRGSFQPPVCNK LMHQEQLKVMFIGGPNTRKDYHIEE GEEVFYQLEGDMVLRVLEQGKHRDV VIRQGEIFLLPARVPHSPQRFANTV GLVVERRRLETELDGLRYYVGDTMD VLFEKWFYCKDLGTQLAPIIQEFFS SEQYRTGKPIPDQLLKEPPFPLSTR SIMEPMSLDAWLDSHHRELQAGTPL SLFGDTYETQVIAYGQGSSEGLRQN VDVWLWQLEGSSVVTMGGRRLSLAP DDSLLVLAGTSYAWERTQGSVALSV TQDPACKKPLGTRTRPLEQKLISEE DLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
