| Description : |
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
41.8 kDa |
| AA Sequence : |
MNRHHLQDHFLEIDKKNCCVFRDDF IVKVLPPVLGLEFIFGLLGNGLALW IFCFHLKSWKSSRIFLFNLAVADFL LIICLPFLMDNYVRRWDWKFGDIPC RLMLFMLAMNRQGSIIFLTVVAVDR YFRVVHPHHALNKISNRTAAIISCL LWGITIGLTVHLLKKKMPIQNGGAN LCSSFSICHTFQWHEAMFLLEFFLP LGIILFCSARIIWSLRQRQMDRHAK IKRAITFIMVVAIVFVICFLPSVVV RIRIFWLLHTSGTQNCEVYRSVDLA FFITLSFTYMNSMLDPVVYYFSSPS FPNFFSTLINRCLQRKMTGEPDNNR STSVELTGDPNKTRGAPEALMANSG EPWSPSYLGPTSPTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
