Recombinant Human HCK Protein (I81-P526), His tagged

• Cat.No.: HCK-0758H
• Product Overview: Recombinant Human 8His-TEV-HCK(I81-P526 end)(Q523E, Q524E, Q525I) Protein was expressed in Insect cell.

Specification

• Description: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: I81-P526
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: HCK hemopoietic cell kinase [ Homo sapiens (human) ]
• Official Symbol: HCK
• Synonyms: HCK; hemopoietic cell kinase; tyrosine-protein kinase HCK; JTK9; p59-HCK/p60-HCK; hematopoietic cell kinase; p59Hck; p61Hck
• Gene ID: 3055
• mRNA Refseq: NM_001172129
• Protein Refseq: NP_001165600
• MIM: 142370
• UniProt ID: P08631