Recombinant Human HDAC4 Protein, GST-tagged

• Cat.No.: HDAC4-022H
• Product Overview: Recombinant Human HDAC4 protein (627-1085) with a N-terminal GST-tag was expressed in baculovirus expression system

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
• Source: Insect Cells
• Species: Human
• Tag: GST
• Molecular Mass: 75.2 kDa
• Protein length: 627-1085
• Purity: 60% estimated by SDS-PAGE
• Unit Definition: One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/ml BSA, and 20 µM fluorogenic HDAC class 2a substrate.
• Stability: ≥ 6 months
• Storage: -80 centigrade
• Storage Buffer: 45 mM Tris-HCl, pH 8.0, with 124 mM NaCl, 2.4 mM KCl, 18 mM glutathione, and 10% glycerol
• Shipping: Dry ice in continental US, may vary elsewhere.

Gene Information

• Gene Name: HDAC4 histone deacetylase 4 [ Homo sapiens (human) ]
• Official Symbol: HDAC4
• Synonyms: HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; histone deacetylase 4; histone deacetylase A; EC 3.5.1.98
• Gene ID: 9759
• mRNA Refseq: NM_006037
• Protein Refseq: NP_006028
• MIM: 605314
• UniProt ID: P56524