Recombinant Human HSP90AB1 Protein (Met1-Asp724), His tagged

• Cat.No.: HSP90AB1-3471H
• Product Overview: Recombinant human HSP90AB1 (Met1-Asp724) protein fused with His tag was expressed in E. coli.

Specification

• Description: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 79.28 kDa
• Protein Length: Met1-Asp724
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 [ Homo sapiens (human) ]
• Official Symbol: HSP90AB1
• Synonyms: HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock 90kD protein 1, beta, heat shock 90kDa protein 1, beta, HSPC2, HSPCB; heat shock protein HSP 90-beta; heat shock 84 kDa; heat shock protein beta; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; 90-kda heat shock protein beta HSP90 beta; HSP84; HSPC2; HSPCB; D6S182; HSP90B; HSP90-BETA; FLJ26984
• Gene ID: 3326
• mRNA Refseq: NM_007355
• Protein Refseq: NP_031381
• MIM: 140572
• UniProt ID: P08238