Recombinant Human HSP90B1, His-tagged

• Cat.No.: HSP90B1-27413TH
• Product Overview: Recombinant fragment, corresponding to amino acids 341-803 of Human GRP94 with N terminal His tag; 463 amino acids, 57kDa.

Specification

• Description: HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 is an endoplasmic reticulum HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and mitochondria (TRAP1; MIM 606219) (Chen et al.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitute with 89 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Store at 4°C. Upon reconstitution store at -80oC.
• Sequences of amino acids: PIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGE VTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFI TDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLK VIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGV IEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEK QDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDE YCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVE KEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVAS QYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPR HPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYL LPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEET AEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL
• Sequence Similarities: Belongs to the heat shock protein 90 family.

Gene Information

• Gene Name: HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 [ Homo sapiens ]
• Official Symbol: HSP90B1
• Synonyms: HSP90B1; heat shock protein 90kDa beta (Grp94), member 1; TRA1, tumor rejection antigen (gp96) 1; endoplasmin; GP96; GRP94
• Gene ID: 7184
• mRNA Refseq: NM_003299
• Protein Refseq: NP_003290
• MIM: 191175
• Uniprot ID: P14625
• Chromosome Location: 12q24.2-q24.3
• Pathway: Activation of Chaperones by ATF6-alpha, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; IL6-mediated signaling events, organism-specific biosystem; NOD-like receptor signaling pathway, organism-specific biosystem; NOD-like receptor signaling pathway, conserved biosystem
• Function: ATP binding; RNA binding; calcium ion binding; low-density lipoprotein particle receptor binding; nucleotide binding