Recombinant Human Hypoxia Inducible Factor 1, Alpha Subunit Inhibitor
Cat.No. : | HIF1AN-5022H |
Product Overview : | Recombinant human HIF1AN protein was expressed in E. coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | HIF1AN-5022H |
Description : | Hypoxia-inducible factor 1, alpha subunit inhibitor (HIF1AN), a member of the Fe2+ and 2-oxoglutarate-dependent dioxygenase superfamily, is a protein that hydoxylates a specific asparagine residue (Asn-803) within the HIF1alpha C-terminal transactivation domain. In normoxia, the HIF1AN-mediated hydroxylation of the HIF1alpha transactivation domain results in blockage of the HIF1alpha-p300/CBP interaction and represses transcriptional activity of HIF1alpha-targeted genes. |
Concentration : | 1 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0. |
Purity : | > 90% by SDS - PAGE |
Sequence : | 1-349 amino acids: MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKR |
Molecular Mass : | 40.2 kDa (349 aa), confirmed by MALDI-TOF. |
Applications : | SDS-PAGE |
Storage : | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Gene Name : | HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor [ Homo sapiens ] |
Official Symbol : | HIF1AN |
Synonyms : | HIF1AN; DKFZp762F1811; FIH1; FLJ20615; FLJ22027; hypoxia inducible factor 1, alpha subunit inhibitor; OTTHUMP00000020284; factor inhibiting HIF1; peptide-aspartate beta-dioxygenase; DKFZp762F1811; EC 1.14.11.16; FIH-1; Factor inhibiting HIF-1; Hypoxia-inducible factor asparagine hydroxylase; factor inhibiting HIF1; hypoxia-inducible factor 1, alpha subunit inhibitor |
Gene ID : | 55662 |
mRNA Refseq : | NM_017902 |
Protein Refseq : | NP_060372 |
MIM : | 606615 |
UniProt ID : | Q9NWT6 |
Chromosome Location : | 10q24 |
Pathway : | HIF-2-alpha transcription factor network; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Function : | iron ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two; atoms of oxygen; peptide-aspartate beta-dioxygenase activity; protein binding |
Products Types
◆ Recombinant Protein | ||
HIF1AN-4748H | Recombinant Human HIF1AN Protein, GST-tagged | +Inquiry |
HIF1AN-1069H | Recombinant Human HIF1AN Protein, His (Fc)-Avi-tagged | +Inquiry |
HIF1AN-4162M | Recombinant Mouse HIF1AN Protein, His (Fc)-Avi-tagged | +Inquiry |
Hif1an-3394M | Recombinant Mouse Hif1an Protein, Myc/DDK-tagged | +Inquiry |
HIF1AN-448H | Recombinant Human HIF1AN Protein, His-tagged | +Inquiry |
◆ Lysates | ||
HIF1AN-5564HCL | Recombinant Human HIF1AN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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