| Description : |
This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
72.67 kDa |
| AA Sequence : |
MRPLRPRAALLALLASLLAAPPVAP AEAPHLVHVDAARALWPLRRFWRST GFCPPLPHSQADQYVLSWDQQLNLA YVGAVPHRGIKQVRTHWLLELVTTR GSTGRGLSYNFTHLDGYLDLLRENQ LLPGFELMGSASGHFTDFEDKQQVF EWKDLVSSLARRYIGRYGLAHVSKW NFETWNEPDHHDFDNVSMTMQGFLN YYDACSEGLRAASPALRLGGPGDSF HTPPRSPLSWGLLRHCHDGTNFFTG EAGVRLDYISLHRKGARSSISILEQ EKVVAQQIRQLFPKFADTPIYNDEA DPLVGWSLPQPWRADVTYAAMVVKV IAQHQNLLLANTTSAFPYALLSNDN AFLSYHPHPFAQRTLTARFQVNNTR PPHVQLLRKPVLTAMGLLALLDEEQ LWAEVSQAGTVLDSNHTVGVLASAH RPQGPADAWRAAVLIYASDDTRAHP NRSVAVTLRLRGVPPGPGLVYVTRY LDNGLCSPDGEWRRLGRPVFPTAEQ FRRMRAAEDPVAAAPRPLPAGGRLT LRPALRLPSLLLVHVCARPEKPPGQ VTRLRALPLTQGQLVLVWSDEHVGS KCLWTYEIQFSQDGKAYTPVSRKPS TFNLFVFSPDTGAVSGSYRVRALDY WARPGPFSDPVPYLEVPVPRGPPSP GNPSGPTRTRRLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
