Recombinant Human IFNA4 Protein (Ala10-Ala163), His tagged

• Cat.No.: IFNA4-3597H
• Product Overview: Recombinant human IFNA4 (Ala10-Ala163) protein fused with His tag was expressed in E. coli.

Specification

• Description: Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 22 and 41 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 18.86 kDa
• Protein Length: Ala10-Ala163
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: IFNA4 interferon, alpha 4 [ Homo sapiens (human) ]
• Official Symbol: IFNA4
• Synonyms: IFNA4; interferon, alpha 4; interferon alpha-4; IFN alpha4a; MGC142200; IFN-alpha-4; interferon alpha-4B; interferon alpha-76; interferon alpha-M1; INFA4; IFN-alpha4a
• Gene ID: 3441
• mRNA Refseq: NM_021068
• Protein Refseq: NP_066546
• MIM: 147564
• UniProt ID: P05014