Recombinant Human IGF1R
Cat.No. : | IGF1R-29118TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 930-1337 of the cytoplasmic domain of Human IGF1 Receptor beta subunit fused with a proprietary tag; expressed in a baculovirus infected Sf9 cells, 72.3 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. |
Biological activity : | Specific activity: ~100 nmol/min/mg at 25°C using poly(Glu:Tyr)4:1 substrate.Reaction conditions are 50 mM Tris, pH 7.5, 5 mM MgCl2, 5 mM MnCl2, 1 mM DTT, 250 μM ATP. The kinase concentration was 0.5-1 μM and poly-L-lysine was added in equimolar amounts t |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 50mM Tris, 1mM DTT, pH 7.5 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Gene Name : | IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ] |
Official Symbol : | IGF1R |
Synonyms : | IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; |
Gene ID : | 3480 |
mRNA Refseq : | NM_000875 |
Protein Refseq : | NP_000866 |
MIM : | 147370 |
Uniprot ID : | P08069 |
Chromosome Location : | 15q26.3 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Apoptosis, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; |
Function : | ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; |
Products Types
◆ Recombinant Protein | ||
IGF1R-2589H | Recombinant Human IGF1R protein(761-930 aa), C-His-tagged | +Inquiry |
IGF1R-0995H | Recombinant Human IGF1R Protein (S982-K1286), His tagged | +Inquiry |
IGF1R-063H | Recombinant Human IGF1R Protein, C-His-tagged | +Inquiry |
IGF1R-1154H | Recombinant Human IGF1R Protein, His (Fc)-Avi-tagged | +Inquiry |
IGF1R-22M | Active Recombinant Mouse IGF1R Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IGF1R-2928HCL | Recombinant Human IGF1R cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1601 | HEK 293 IGF1R Bioassay Kit | +Inquiry |
Kit-1600 | IGF1R Functional Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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