Recombinant Human IKZF1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | IKZF1-2552H |
Product Overview : | IKZF1 MS Standard C13 and N15-labeled recombinant protein (NP_006051) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 57.3 kDa |
AA Sequence : | MDADEGQDMSQVSGKESPPVSDTPD EGDEPMPIPEDLSTTSGGQQSSKSD RVVASNVKVETQSDEENGRACEMNG EECAEDLRMLDASGEKMNGSHRDQG SSALSGVGGIRLPNGKLKCDICGII CIGPNVLMVHKRSHTGERPFQCNQC GASFTQKGNLLRHIKLHSGEKPFKC HLCNYACRRRDALTGHLRTHSVGKP HKCGYCGRSYKQRSSLEEHKERCHN YLESMGLPGTLYPVIKEETNHSEMA EDLCKIGSERSLVLDRLASNVAKRK SSMPQKFLGDKGLSDTPYDSSASYE KENEMMKSHVMDQAINNAINYLGAE SLRPLVQTPPGGSEVVPVISPMYQL HKPLAEGTPRSNHSAQDSAVENLLL LSKAKLVPSEREASPSNSCQDSTDT ESNNEEQRSGLIYLTNHIAPHARNG LSLKEEHRAYDLLRAASENSQDALR VVSTSGEQMKVYKCEHCRVLFLDHV MYTIHMGCHGFRDPFECNMCGYHSQ DRYEFSSHITRGEHRFHMSTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | IKZF1 IKAROS family zinc finger 1 [ Homo sapiens (human) ] |
Official Symbol : | IKZF1 |
Synonyms : | IKZF1; IKAROS family zinc finger 1 (Ikaros); zinc finger protein, subfamily 1A, 1 (Ikaros), ZNFN1A1; DNA-binding protein Ikaros; hIk 1; Hs.54452; IKAROS; LyF 1; CLL-associated antigen KW-6; Ikaros (zinc finger protein); ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; zinc finger protein, subfamily 1A, 1 (Ikaros); IK1; LYF1; hIk-1; PRO0758; ZNFN1A1; |
Gene ID : | 10320 |
mRNA Refseq : | NM_006060 |
Protein Refseq : | NP_006051 |
MIM : | 603023 |
UniProt ID : | Q13422 |
Products Types
◆ Recombinant Protein | ||
Ikzf1-3498M | Recombinant Mouse Ikzf1 Protein, Myc/DDK-tagged | +Inquiry |
IKZF1-6645C | Recombinant Chicken IKZF1 | +Inquiry |
IKZF1-8622Z | Recombinant Zebrafish IKZF1 | +Inquiry |
IKZF1-4416H | Recombinant Human IKZF1 protein, His-Avi-tagged | +Inquiry |
IKZF1-125H | Recombinant Human IKZF1 protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
IKZF1-850HCL | Recombinant Human IKZF1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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