Description : |
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
30.2 kDa |
AA Sequence : |
MADPWQECMDYAVTLARQAGEVVCE AIKNEMNVMLKSSPVDLVTATDQKV EKMLISSIKEKYPSHSFIGEESVAA GEKSILTDNPTWIIDPIDGTTNFVH RFPFVAVSIGFAVNKKIEFGVVYSC VEGKMYTARKGKGAFCNGQKLQVSQ QEDITKSLLVTELGSSRTPETVRMV LSNMEKLFCIPVHGIRSVGTAAVNM CLVATGGADAYYEMGIHCWDVAGAG IIVTEAGGVLMDVTGGPFDLMSRRV IAANNRILAERIAKEIQVIPLQRDD EDTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |