Recombinant Human IMPDH1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: IMPDH1-4548H
• Product Overview: IMPDH1 MS Standard C13 and N15-labeled recombinant protein (NP_000874) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 64.1 kDa
• AA Sequence: MEGPLTPPPLQGGGAAAVPEPGARQ HPGHETAAQRYSARLLQAGYEPESP RLDLATHPTTPRSELSSVVLLAGVG VQMDRLRRASMADYLISGGTGYVPE DGLTAQQLFASADGLTYNDFLILPG FIDFIADEVDLTSALTRKITLKTPL ISSPMDTVTEADMAIAMALMGGIGF IHHNCTPEFQANEVRKVKKFEQGFI TDPVVLSPSHTVGDVLEAKMRHGFS GIPITETGTMGSKLVGIVTSRDIDF LAEKDHTTLLSEVMTPRIELVVAPA GVTLKEANEILQRSKKGKLPIVNDC DELVAIIARTDLKKNRDYPLASKDS QKQLLCGAAVGTREDDKYRLDLLTQ AGVDVIVLDSSQGNSVYQIAMVHYI KQKYPHLQVIGGNVVTAAQAKNLID AGVDGLRVGMGCGSICITQEVMACG RPQGTAVYKVAEYARRFGVPIIADG GIQTVGHVVKALALGASTVMMGSLL AATTEAPGEYFFSDGVRLKKYRGMG SLDAMEKSSSSQKRYFSEGDKVKIA QGVSGSIQDKGSIQKFVPYLIAGIQ HGCQDIGARSLSVLRSMMYSGELKF EKRTMSAQIEGGVHGLHSYEKRLYT RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: IMPDH1 inosine monophosphate dehydrogenase 1 [ Homo sapiens (human) ]
• Official Symbol: IMPDH1
• Synonyms: IMPDH1; IMP (inosine 5-monophosphate) dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1, retinitis pigmentosa 10 (autosomal dominant), RP10; inosine-5-monophosphate dehydrogenase 1; LCA11; sWSS2608; IMPD 1; IMPDH 1; IMPDH-I; IMP dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1; IMPD; RP10; IMPD1; DKFZp781N0678
• Gene ID: 3614
• mRNA Refseq: NM_000883
• Protein Refseq: NP_000874
• MIM: 146690
• UniProt ID: P20839