Recombinant Human ING2 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | ING2-2064H |
Product Overview : | ING2 MS Standard C13 and N15-labeled recombinant protein (NP_001555) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 32.8 kDa |
AA Sequence : | MLGQQQQQLYSSAALLTGERSRLLT CYVQDYLECVESLPHDMQRNVSVLR ELDNKYQETLKEIDDVYEKYKKEDD LNQKKRLQQLLQRALINSQELGDEK IQIVTQMLELVENRARQMELHSQCF QDPAESERASDKAKMDSSQPERSSR RPRRQRTSESRDLCHMANGIEDCDD QPPKEKKSKSAKKKKRSKAKQEREA SPVEFAIDPNEPTYCLCNQVSYGEM IGCDNEQCPIEWFHFSCVSLTYKPK GKWYCPKCRGDNEKTMDKSTEKTKK DRRSRTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | ING2 inhibitor of growth family member 2 [ Homo sapiens (human) ] |
Official Symbol : | ING2 |
Synonyms : | ING2; inhibitor of growth family, member 2; ING1L, inhibitor of growth family, member 1 like; inhibitor of growth protein 2; p33ING2; p32; ING1Lp; inhibitor of growth 1-like protein; ING1L; |
Gene ID : | 3622 |
mRNA Refseq : | NM_001564 |
Protein Refseq : | NP_001555 |
MIM : | 604215 |
UniProt ID : | Q9H160 |
Products Types
◆ Recombinant Protein | ||
ING2-2090R | Recombinant Rhesus Macaque ING2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ING2-5130H | Recombinant Human ING2 Protein, GST-tagged | +Inquiry |
ING2-4543M | Recombinant Mouse ING2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ing2-3536M | Recombinant Mouse Ing2 Protein, Myc/DDK-tagged | +Inquiry |
ING2-8208M | Recombinant Mouse ING2 Protein | +Inquiry |
◆ Lysates | ||
ING2-5208HCL | Recombinant Human ING2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionChronic AngⅡ infusion increased myocardial expression levels of Ac-p53(Lys382) and p-p53(Ser15), and Ing2 silencing prior to AngⅡ infusion reduced the increase in Ac-p53(Lys382) without affecting p53(Ser15) expression.
Ing2 mRNA and protein levels were significantly higher in mice with chronic Ang Ⅱ infusion compared to saline-infused mice.
The conclusion is that Ing2 silencing can inhibit AngⅡ-induced cardiac remodeling and dysfunction in mice by reducing p53 acetylation.
Ing2 silencing significantly alleviated AngⅡ-induced cardiac function decline, as evidenced by reduced LVEDD and LVESD and increased LVEF and LVFS.
The study suggests that the reduction of p53 acetylation by Ing2 silencing contributes to the prevention of cardiac remodeling and dysfunction in response to chronic AngⅡ infusion.
Chronic AngⅡ infusion led to increased left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) and reduced left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) in the mice.
Ing2 silencing improved myocardial mitochondrial damage, reduced myocardial hypertrophy and fibrosis, and inhibited cardiomyocyte apoptosis induced by chronic AngⅡ infusion.
Customer Reviews (3)
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Consistently achieving specific outcomes validated the pivotal role of the product in our research studies.
The product's unique attributes propelled our research to innovative heights.
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