Recombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, GST-tagged
Cat.No. : | IKBKB-1027H |
Product Overview : | Full length recombinant human IKBKB was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IKBKB-1027H |
Description : | IKBKB is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKBKB is stimulated by TNF and IL1 and IKBKB forms a heterodimer that interacts with NIK. Overexpression of catalytically inactive IKBKB blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKBKB activity in vitro and in vivo by binding to IKBKB to reduce ATP binding. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 105 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0,25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Specific Activity : | 12 mmol/min/mg |
Purity : | > 95 % |
Concentration : | 0.1 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Acute myeloid leukemia; Adipocytokine signaling pathway; Apoptosis; B cell receptor signaling pathway; Chagas disease; Neurotrophin signaling pathway; Pancreatic cancer; Pathways in cancer; Prostate cancer; RIG-I-like receptor signaling pathway; Shigellosis; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus |
Gene Name : | IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [ Homo sapiens ] |
Official Symbol : | IKBKB |
Synonyms : | IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta; EC 2.7.11.10 |
Gene ID : | 3551 |
mRNA Refseq : | NM_001190720 |
Protein Refseq : | NP_001177649 |
MIM : | 603258 |
UniProt ID : | O14920 |
Chromosome Location : | 8p11.2 |
Function : | ATP binding; IkappaB kinase activity; identical protein binding; nucleotide binding; protein binding; protein heterodimerization activity; transcription activator activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
IKBKB-501H | Recombinant Human IKBKB Protein, MYC/DDK-tagged | +Inquiry |
IKBKB-87H | Recombinant Human IKBKB Protein, His-tagged | +Inquiry |
IKBKB-1064H | Recombinant Human IKBKB Protein (S695-S756), Tag Free | +Inquiry |
IKBKB-1162H | Recombinant Human IKBKB Protein, His (Fc)-Avi-tagged | +Inquiry |
IKBKB-2046R | Recombinant Rhesus Macaque IKBKB Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IKBKB-849HCL | Recombinant Human IKBKB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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