Recombinant Human IRF9 Protein (Met1-Val393), His tagged

• Cat.No.: IRF9-3413H
• Product Overview: Recombinant human IRF9 (Met1-Val393) protein fused with His tag was expressed in E. coli.

Specification

• Description: Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 44.67 kDa
• Protein Length: Met1-Val393
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: IRF9 interferon regulatory factor 9 [ Homo sapiens (human) ]
• Official Symbol: IRF9
• Synonyms: IRF9; interferon regulatory factor 9; interferon stimulated transcription factor 3, gamma (48kD), interferon stimulated transcription factor 3, gamma 48kDa, ISGF3G; ISGF-3 gamma; ISGF3 p48 subunit; interferon-stimulated gene factor 3 gamma; transcriptional regulator ISGF3 subunit gamma; IFN-alpha-responsive transcription factor subunit; interferon-stimulated transcription factor 3, gamma 48kDa; interferon-stimulated transcription factor 3, gamma (48kD); p48; IRF-9; ISGF3; ISGF3G
• Gene ID: 10379
• mRNA Refseq: NM_006084
• Protein Refseq: NP_006075
• MIM: 147574
• UniProt ID: Q00978