Recombinant Human ITGB4 Protein, GST-tagged

• Cat.No.: ITGB4-4972H
• Product Overview: Human ITGB4 partial ORF ( NP_000204, 28 a.a. - 137 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 37.84 kDa
• AA Sequence: NRCKKAPVKSCTECVRVDKDCAYCT DEMFRDRRCNTQAELLAAGCQRESI VVMESSFQITEETQIDTTLRRSQMS PQGLRVRLRPGEERHFELEVFEPLE SPVDLYILMD
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ITGB4 integrin, beta 4 [ Homo sapiens ]
• Official Symbol: ITGB4
• Synonyms: ITGB4; integrin, beta 4; integrin beta-4; CD104; GP150; CD104 antigen; integrin beta-4 subunit
• Gene ID: 3691
• mRNA Refseq: NM_000213
• Protein Refseq: NP_000204
• MIM: 147557
• UniProt ID: P16144