Recombinant Human IVD, His-tagged

• Cat.No.: IVD-29875TH
• Product Overview: Recombinant full length Human IVD with a N terminal His tag; 415aa, 45.3 kDa.

Specification

• Description: Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Protein length: 394 amino acids
• Conjugation: HIS
• Molecular Weight: 45.300kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 10% Glycerol
• Storage: Please see Notes section
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MHSLLPVDDA INGLSEEQRQ LRQTMAKFLQ EHLAPKAQEI DRSNEFKNLR EFWKQLGNLG VLGITAPVQY GGSGLGYLEH VLVMEEISRA SGAVGLSYGA HSNLCINQLV RNGNEAQKEK YLPKLISGEY IGALAMSEPN AGSDVVSMKL KAEKKGNHYI LNGNKFWITN GPDADVLIVY AKTDLAAVPA SRGITAFIVE KGMPGFSTSK KLDKLGMRGS NTCELIFEDC KIPAANILGH ENKGVYVLMS GLDLERLVLA GGPLGLMQAV LDHTIPYLHV REAFGQKIGH FQLMQGKMAD MYTRLMACRQ YVYNVAKACD EGHCTAKDCA GVILYSAECA TQVALDGIQC FGGNGYINDF PMGRFLRDAK LYEIGAGTSE VRRLVIGRAF NADFH
• Sequence Similarities: Belongs to the acyl-CoA dehydrogenase family.

Gene Information

• Gene Name: IVD isovaleryl-CoA dehydrogenase [ Homo sapiens ]
• Official Symbol: IVD
• Synonyms: IVD; isovaleryl-CoA dehydrogenase; isovaleryl CoA dehydrogenase , isovaleryl Coenzyme A dehydrogenase; isovaleryl-CoA dehydrogenase, mitochondrial; ACAD2
• Gene ID: 3712
• mRNA Refseq: NM_001159508
• Protein Refseq: NP_001152980
• MIM: 607036
• Uniprot ID: P26440
• Chromosome Location: 15q14-q15
• Pathway: Branched-chain amino acid catabolism, organism-specific biosystem; Leucine degradation, leucine => acetoacetate + acetyl-CoA, organism-specific biosystem; Leucine degradation, leucine => acetoacetate + acetyl-CoA, conserved biosystem
• Function: flavin adenine dinucleotide binding; isovaleryl-CoA dehydrogenase activity; isovaleryl-CoA dehydrogenase activity

Reviews

03/13/2019

After a prolonged quest, I have finally discovered such a steadfast and dependable protein reagent that plays an indispensable role in my research endeavors.

05/29/2017

This protein reagent is truly marvelous, providing stability and reliability, while becoming an invaluable assistant in my experiments.

07/19/2016

The unwavering high quality of this protein substance instills confidence in the accuracy of my experimental results.