| Description : |
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
81.7 kDa |
| AA Sequence : |
MEVMNLMEQPIKVTEWQQTYTYDSG IHSGANTCVPSVSSKGIMEEDEACG RQYTLKKTTTYTQGVPPSQGDLEYQ MSTTARAKRVREAMCPGVSGEDSSL LLATQVEGQATNLQRLAEPSQLLKS AIVHLINYQDDAELATRALPELTKL LNDEDPVVVTKAAMIVNQLSKKEAS RRALMGSPQLVAAVVRTMQNTSDLD TARCTTSILHNLSHHREGLLAIFKS GGIPALVRMLSSPVESVLFYAITTL HNLLLYQEGAKMAVRLADGLQKMVP LLNKNNPKFLAITTDCLQLLAYGNQ ESKLIILANGGPQALVQIMRNYSYE KLLWTTSRVLKVLSVCPSNKPAIVE AGGMQALGKHLTSNSPRLVQNCLWT LRNLSDVATKQEGLESVLKILVNQL SVDDVNVLTCATGTLSNLTCNNSKN KTLVTQNSGVEALIHAILRAGDKDD ITEPAVCALRHLTSRHPEAEMAQNS VRLNYGIPAIVKLLNQPNQWPLVKA TIGLIRNLALCPANHAPLQEAAVIP RLVQLLVKAHQDAQRHVAAGTQQPY TDGVRMEEIVEGCTGALHILARDPM NRMEIFRLNTIPLFVQLLYSSVENI QRVAAGVLCELAQDKEAADAIDAEG ASAPLMELLHSRNEGTATYAAAVLF RISEDKNPDYRKRVSVELTNSLFKH DPAAWEAAQSMIPINEPYGDDLDAT YRPMYSSDVPLDPLEMHMDMDGDYP IDTYSDGLRPPYPTADHMLATRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
