| Description : |
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. |
| Source : |
Insect cells |
| Species : |
Human |
| Tag : |
His |
| Form : |
50mMTris-HCl, pH 8.0, 250mMNaCl |
| Molecular Mass : |
～100KDa |
| AA sequence : |
MSEAGGAGPGGCGAGAGAGAGPGAL PPQPAALPPAPPQGSPCAAAAGGSG ACGPATAVAAAGTAEGPGGGGSARI AVKKAQLRSAPRAKKLEKLGVYSAC KAEESCKCNGWKNPNPSPTPPRADL QQIIVSLTESCRSCSHALAAHVSHL ENVSEEEMNRLLGIVLDVEYLFTCV HKEEDADTKQVYFYLFKLLRKSILQ RGKPVVEGSLEKKPPFEKPSIEQGV NNFVQYKFSHLPAKERQTIVELAKM FLNRINYWHLEAPSQRRLRSPNDDI SGYKENYTRWLCYCNVPQFCDSLPR YETTQVFGRTLLRSVFTVMRRQLLE QARQEKDKLPLEKRTLILTHFPKFL SMLEEEVYSQNSPIWDQDFLSASSR TSQLGIQTVINPPPVAGTISYNSTS SSLEQPNAGSSSPACKASSGLEANP GEKRKMTDSHVLEEAKKPRVMGDIP MELINEVMSTITDPAAMLGPETNFL SAHSARDEAARLEERRGVIEFHVVG NSLNQKPNKKILMWLVGLQNVFSHQ LPRMPKEYITRLVFDPKHKTLALIK DGRVIGGICFRMFPSQGFTEIVFCA VTSNEQVKGYGTHLMNHLKEYHIKH DILNFLTYADEYAIGYFKKQGFSKE IKIPKTKYVGYIKDYEGATLMGCEL NPRIPYTEFSVIIKKQKEIIKKLIE RKQAQIRKVYPGLSCFKDGVRQIPI ESIPGIRETGWKPSGKEKSKEPRDP DQLYSTLKSILQQVKSHQSAWPFME PVKRTEAPGYYEVIRFPMDLKTMSE RLKNRYYVSKKLFMADLQRVFTNCK EYNPPESEYYKCANILEKFFFSKIK EAGLIDK |
| Purity : |
>90% as determined by SDS-PAGE |
| Storage : |
Short Term Storage at +4 centigrade, Long Term Storage at -20 centigrade to -80 centigrade. Avoid freeze/thaw cycles. |
