Recombinant Human KCNIP3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: KCNIP3-2355H
• Product Overview: KCNIP3 MS Standard C13 and N15-labeled recombinant protein (NP_038462) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 29.2 kDa
• AA Sequence: MQPAKEVTKASDGSLLGDLGHTPLS KKEGIKWQRPRLSRQALMRCCLVKW ILSSTAPQGSDSSDSELELSTVRHQ PEGLDQLQAQTKFTKKELQSLYRGF KNECPTGLVDEDTFKLIYAQFFPQG DATTYAHFLFNAFDADGNGAIHFED FVVGLSILLRGTVHEKLKWAFNLYD INKDGYITKEEMLAIMKSIYDMMGR HTYPILREDAPAEHVERFFEKMDRN QDGVVTIEEFLEACQKDENIMSSMQ LFENVITRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: KCNIP3 potassium voltage-gated channel interacting protein 3 [ Homo sapiens (human) ]
• Official Symbol: KCNIP3
• Synonyms: KCNIP3; Kv channel interacting protein 3, calsenilin; calsenilin, presenilin binding protein, EF hand transcription factor, CSEN; calsenilin; DREAM; KCHIP3; DRE-antagonist modulator; kv channel-interacting protein 3; potassium channel interacting protein 3; A-type potassium channel modulatory protein 3; calsenilin, presenilin-binding protein, EF hand transcription factor; CSEN; MGC18289
• Gene ID: 30818
• mRNA Refseq: NM_013434
• Protein Refseq: NP_038462
• MIM: 604662
• UniProt ID: Q9Y2W7