Recombinant Human KDM2A protein, FLAG-tagged
Cat.No. : | KDM2A-46H |
Product Overview : | Recombinant Human KDM2A(a.a: 2-700) fused with FLAG tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | Lysine (K)-specific demethylase 2A (KDM2A), also known as FBXL11, JHDM1A, CXXC8, nucleates at CpG islands and specifically demethylates "Lys-36" of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 "Lys-36" residue while it has weak or no activity for mono- and tri-methylated H3 "Lys-36". May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. |
Source : | Insect cells |
Species : | Human |
Tag : | FLAG |
Form : | In 25 mM Tris pH 8.0, 300 mM NaCl, 5% Glycerol, 0.04% Triton X-100 and 0.2 mg/ml 3× Flag peptide. |
Molecular Mass : | 128 kDa |
Applications : | Recombinant KDM2A / FBXL11 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
Storage : | Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
Concentration : | 0.25 μg/μl |
Gene Name : | KDM2A lysine (K)-specific demethylase 2A [ Homo sapiens ] |
Official Symbol : | KDM2A |
Synonyms : | KDM2A; lysine (K)-specific demethylase 2A; F box and leucine rich repeat protein 11 , FBXL11; lysine-specific demethylase 2A; CXXC8; DKFZP434M1735; F box protein FBL11; FBL7; FBL11; FLJ00115; JHDM1A; jumonji C domain containing histone demethylase 1A; KIAA1004; LILINA; F-box/LRR-repeat protein 11; CXXC-type zinc finger protein 8; [Histone-H3]-lysine-36 demethylase 1A; F-box and leucine-rich repeat protein 11; jumonji C domain-containing histone demethylase 1A; jmjC domain-containing histone demethylation protein 1A; FBXL11; FLJ46431; DKFZp434M1735; |
Gene ID : | 22992 |
mRNA Refseq : | NM_012308 |
Protein Refseq : | NP_036440 |
MIM : | 605657 |
UniProt ID : | Q9Y2K7 |
Chromosome Location : | 11q13.1 |
Function : | DNA binding; histone demethylase activity (H3-K36 specific); metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; zinc ion binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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