Recombinant Human KEAP1 Protein (1-624 aa), His-tagged
Cat.No. : | KEAP1-2185H |
Product Overview : | Recombinant Human KEAP1 Protein (1-624 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Epigenetics and Nuclear Signaling. Protein Description: Full Length. |
- Specification
- Gene Information
- Related Products
Description : | Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. |
Source : | Yeast |
Species : | Human |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 71.7 kDa |
Protein length : | 1-624 aa |
AA Sequence : | MQPDPRPSGAGACCRFLPLQSQCPE GAGDAVMYASTECKAEVTPSQHGNR TFSYTLEDHTKQAFGIMNELRLSQQ LCDVTLQVKYQDAPAAQFMAHKVVL ASSSPVFKAMFTNGLREQGMEVVSI EGIHPKVMERLIEFAYTASISMGEK CVLHVMNGAVMYQIDSVVRACSDFL VQQLDPSNAIGIANFAEQIGCVELH QRAREYIYMHFGEVAKQEEFFNLSH CQLVTLISRDDLNVRCESEVFHACI NWVKYDCEQRRFYVQALLRAVRCHS LTPNFLQMQLQKCEILQSDSRCKDY LVKIFEELTLHKPTQVMPCRAPKVG RLIYTAGGYFRQSLSYLEAYNPSDG TWLRLADLQVPRSGLAGCVVGGLLY AVGGRNNSPDGNTDSSALDCYNPMT NQWSPCAPMSVPRNRIGVGVIDGHI YAVGGSHGCIHHNSVERYEPERDEW HLVAPMLTRRIGVGVAVLNRLLYAV GGFDGTNRLNSAECYYPERNEWRMI TAMNTIRSGAGVCVLHNCIYAAGGY DGQDQLNSVERYDVETETWTFVAPM KHRRSALGITVHQGRIYVLGGYDGH TFLDSVECYDPDTDTWSEVTRMTSG RSGVGVAVTMEPCRKQIDQQNCTC |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA will be sent along with the products. Please refer to it for detailed information. |
Gene Name : | KEAP1 kelch-like ECH-associated protein 1 [ Homo sapiens ] |
Official Symbol : | KEAP1 |
Synonyms : | KEAP1; INrf2; KIAA0132; KLHL19; MGC1114; MGC4407; MGC9454; MGC10630; MGC20887; |
Gene ID : | 9817 |
mRNA Refseq : | NM_012289 |
Protein Refseq : | NP_036421 |
MIM : | 606016 |
UniProt ID : | Q14145 |
Products Types
◆ Recombinant Protein | ||
Keap1-3686M | Recombinant Mouse Keap1 Protein, Myc/DDK-tagged | +Inquiry |
KEAP1-4789M | Recombinant Mouse KEAP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Keap1-1711R | Recombinant Rat Keap1 Protein, His-tagged | +Inquiry |
KEAP1-2896R | Recombinant Rat KEAP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
KEAP1-3232H | Recombinant Human KEAP1 protein(Gln2-Cys624) | +Inquiry |
◆ Lysates | ||
KEAP1-001HCL | Recombinant Human KEAP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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