Description : |
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
69.7 kDa |
AA Sequence : |
MQPDPRPSGAGACCRFLPLQSQCPE GAGDAVMYASTECKAEVTPSQHGNR TFSYTLEDHTKQAFGIMNELRLSQQ LCDVTLQVKYQDAPAAQFMAHKVVL ASSSPVFKAMFTNGLREQGMEVVSI EGIHPKVMERLIEFAYTASISMGEK CVLHVMNGAVMYQIDSVVRACSDFL VQQLDPSNAIGIANFAEQIGCVELH QRAREYIYMHFGEVAKQEEFFNLSH CQLVTLISRDDLNVRCESEVFHACI NWVKYDCEQRRFYVQALLRAVRCHS LTPNFLQMQLQKCEILQSDSRCKDY LVKIFEELTLHKPTQVMPCRAPKVG RLIYTAGGYFRQSLSYLEAYNPSDG TWLRLADLQVPRSGLAGCVVGGLLY AVGGRNNSPDGNTDSSALDCYNPMT NQWSPCAPMSVPRNRIGVGVIDGHI YAVGGSHGCIHHNSVERYEPERDEW HLVAPMLTRRIGVGVAVLNRLLYAV GGFDGTNRLNSAECYYPERNEWRMI TAMNTIRSGAGVCVLHNCIYAAGGY DGQDQLNSVERYDVETETWTFVAPM KHRRSALGITVHQGRIYVLGGYDGH TFLDSVECYDPDTDTWSEVTRMTSG RSGVGVAVTMEPCRKQIDQQNCTCT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |