Recombinant Human KRT18, His-tagged

• Cat.No.: KRT18-27702TH
• Product Overview: Recombinantfull length protein (Human) with an amino-terminal hexahistidine tag, MW 52 kDa.

Specification

• Description: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the intermediate filament family.

Gene Information

• Gene Name: KRT18 keratin 18 [ Homo sapiens ]
• Official Symbol: KRT18
• Synonyms: KRT18; keratin 18; keratin, type I cytoskeletal 18
• Gene ID: 3875
• mRNA Refseq: NM_000224
• Protein Refseq: NP_000215
• MIM: 148070
• Uniprot ID: P05783
• Chromosome Location: 12q13
• Pathway: Caspase cascade in apoptosis, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Pathogenic Escherichia coli infection, organism-specific biosystem; Pathogenic Escherichia coli infection, conserved biosystem
• Function: protein binding; structural molecule activity

Reviews

01/17/2022

The sensitivity is very high, the experimental results are very good, and the unnecessary trouble is reduced.

10/31/2021

No doping impurities, the experimental effect is very good, will be recommended to other laboratory students.

01/03/2021

Easy to operate, cost-effective.

Q&As

What is the relationship between KRT18 protein and nail diseases?

KRT18 protein may be associated with nail diseases, such as brittle nails, white spots, and longitudinal cracks. These diseases can affect the hardness and structure of the nails, causing them to appear brittle, deformed, and painful.

What is the relationship between KRT18 protein and hair color?

KRT18 protein is not directly related to hair color. Hair color is mainly determined by melanocytes, while the KRT18 protein is mainly involved in the process of keratinization.

How can genetic testing be used to understand the genetic variation of KRT18 protein?

Genetic testing can be done by analyzing DNA sequences to understand genetic variation in the KRT18 protein. These variants may affect the expression level and function of the KRT18 protein, thereby increasing the risk of certain diseases.

How can lifestyle changes affect the function of KRT18 protein?

Lifestyle changes, such as eating a healthy diet, exercising moderately, and avoiding UV damage, can affect the function and expression levels of KRT18 protein. These alterations can promote the normal function of keratinocytes, which can help maintain healthy skin.

How can KRT18 protein-related diseases be prevented?

Prevention of KRT18 protein-related diseases is mainly through maintaining a healthy lifestyle, such as a balanced diet, moderate exercise, maintaining water intake, and avoiding UV damage. In addition, regular skin and oral exams can also help detect potential problems early.

What is the role of KRT18 protein in melanoma?

In melanoma, the KRT18 protein may play a role in promoting tumor growth and metastasis. This may be related to the proliferation and migration of melanoma cells.