| Description : |
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
121 kDa |
| Protein Length : |
1165 |
| AA Sequence : |
MICQKFCVVLLHWEFIYVITAFNLS YPITPWRFKLSCMPPNSTYDYFLLP AGLSKNTSNSNGHYETAVEPKFNSS GTHFSNLSKTTFHCCFRSEQDRNCS LCADNIEGKTFVSTVNSLVFQQIDA NWNIQCWLKGDLKLFICYVESLFKN LFRNYNYKVHLLYVLPEVLEDSPLV PQKGSFQMVHCNCSVHECCECLVPV PTAKLNDTLLMCLKITSGGVIFQSP LMSVQPINMVKPDPPLGLHMEITDD GNLKISWSSPPLVPFPLQYQVKYSE NSTTVIREADKIVSATSLLVDSILP GSSYEVQVRGKRLDGPGIWSDWSTP RVFTTQDVIYFPPKILTSVGSNVSF HCIYKKENKIVPSKEIVWWMNLAEK IPQSQYDVVSDHVSKVTFFNLNETK PRGKFTYDAVYCCNEHECHHRYAEL YVIDVNINISCETDGYLTKMTCRWS TSTIQSLAESTLQLRYHRSSLYCSD IPSIHPISEPKDCYLQSDGFYECIF QPIFLLSGYTMWIRINHSLGSLDSP PTCVLPDSVVKPLPPSSVKAEITIN IGLLKISWEKPVFPENNLQFQIRYG LSGKEVQWKMYEVYDAKSKSVSLPV PDLCAVYAVQVRCKRLDGLGYWSNW SNPAYTVVMDIKVPMRGPEFWRIIN GDTMKKEKNVTLLWKPLMKNDSLCS VQRYVINHHTSCNGTWSEDVGNHTK FTFLWTEQAHTVTVLAINSIGASVA NFNLTFSWPMSKVNIVQSLSAYPLN SSCVIVSWILSPSDYKLMYFIIEWK NLNEDGEIKWLRISSSVKKYYIHDH FIPIEKYQFSLYPIFMEGVGKPKII NSFTQDDIEKHQSDAGLYVIVPVII SSSILLLGTLLISHQRMKKLFWEDV PNPKNCSWAQGLNFQKPETFEHLFI KHTASVTCGPLLLEPETISEDISVD TSWKNKDEMMPTTVVSLLSTTDLEK GSVCISDQFNSVNFSEAEGTEVTYE DESQRQPFVKYATLISNSKPSETGE EQGLINSSVTKCFSSKNSPLKDSFS NSSWEIEAQAFFILSDQHPNIISPH LTFSEGLDELLKLEGNFPEENNDKK SIYYLGVTSIKKRESGVLLTDKSRV SCPFPAPCLFTDIRVLQDSCSHFVE NNINLGTSSKKTFASYMPQFQTCST QTHKIMENKMCDLTV |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
