| Description : |
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
115.5 kDa |
| Protein Length : |
1097 |
| AA Sequence : |
MMDIYVCLKRPSWMVDNKRMRTASN FQWLLSTFILLYLMNQVNSQKKGAP HDLKCVTNNLQVWNCSWKAPSGTGR GTDYEVCIENRSRSCYQLEKTSIKI PALSHGDYEITINSLHDFGSSTSKF TLNEQNVSLIPDTPEILNLSADFST STLYLKWNDRGSVFPHRSNVIWEIK VLRKESMELVKLVTHNTTLNGKDTL HHWSWASDMPLECAIHFVEIRCYID NLHFSGLEEWSDWSPVKNISWIPDS QTKVFPQDKVILVGSDITFCCVSQE KVLSALIGHTNCPLIHLDGENVAIK IRNISVSASSGTNVVFTTEDNIFGT VIFAGYPPDTPQQLNCETHDLKEII CSWNPGRVTALVGPRATSYTLVESF SGKYVRLKRAEAPTNESYQLLFQML PNQEIYNFTLNAHNPLGRSQSTILV NITEKVYPHTPTSFKVKDINSTAVK LSWHLPGNFAKINFLCEIEIKKSNS VQEQRNVTIKGVENSSYLVALDKLN PYTLYTFRIRCSTETFWKWSKWSNK KQHLTTEASPSKGPDTWREWSSDGK NLIIYWKPLPINEANGKILSYNVSC SSDEETQSLSEIPDPQHKAEIRLDK NDYIISVVAKNSVGSSPPSKIASME IPNDDLKIEQVVGMGKGILLTWHYD PNMTCDYVIKWCNSSRSEPCLMDWR KVPSNSTETVIESDEFRPGIRYNFF LYGCRNQGYQLLRSMIGYIEELAPI VAPNFTVEDTSADSILVKWEDIPVE ELRGFLRGYLFYFGKGERDTSKMRV LESGRSDIKVKNITDISQKTLRIAD LQGKTSYHLVLRAYTDGGVGPEKSM YVVTKENSVGLIIAILIPVAVAVIV GVVTSILCYRKREWIKETFYPDIPN PENCKALQFQKSVCEGSSALKTLEM NPCTPNNVEVLETRSAFPKIEDTEI ISPVAERPEDRSDAEPENHVVVSYC PPIIEEEIPNPAADEAGGTAQVIYI DVQSMYQPQAKPEEEQENDPVGGAG YKPQMHLPINSTVEDIAAEEDLDKT AGYRPQANVNTWNLVSPDSPRSIDS NSEIVSFGSPCSINSRQFLIPPKDE DSPKSNGGGWSFTNFFQNKPND |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
