Recombinant Human LIG3 Protein, His-tagged
Cat.No. : | LIG3-1520H |
Product Overview : | Recombinant Human LIG3 Protein with His tag was expressed in E.coli. |
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Description : | This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~103.6 kDa, reducing conditions |
AA Sequence : | MHHHHHHMAEQRFCVDYAKRGTAGC KKCKEKIVKGVCRIGKVVPNPFSES GGDMKEWYHIKCMFEKLERARATTK KIEDLTELEGWEELEDNEKEQITQH IADLSSKAAGTPKKKAVVQAKLTTT GQVTSPVKGASFVTSTNPRKFSGFS AKPNNSGEAPSSPTPKRSLSSSKCD PRHKDCLLREFRKLCAMVADNPSYN TKTQIIQDFLRKGSAGDGFHGDVYL TVKLLLPGVIKTVYNLNDKQIVKLF SRIFNCNPDDMARDLEQGDVSETIR VFFEQSKSFPPAAKSLLTIQEVDEF LLRLSKLTKEDEQQQALQDIASRCT ANDLKCIIRLIKHDLKMNSGAKHVL DALDPNAYEAFKASRNLQDVVERVL HNAQEVEKEPGQRRALSVQASLMTP VQPMLAEACKSVEYAMKKCPNGMFS EIKYDGERVQVHKNGDHFSYFSRSL KPVLPHKVAHFKDYIPQAFPGGHSM ILDSEVLLIDNKTGKPLPFGTLGVH KKAAFQDANVCLFVFDCIYFNDVSL MDRPLCERRKFLHDNMVEIPNRIMF SEMKRVTKALDLADMITRVIQEGLE GLVLKDVKGTYEPGKRHWLKVKKDY LNEGAMADTADLVVLGAFYGQGSKG GMMSIFLMGCYDPGSQKWCTVTKCA GGHDDATLARLQNELDMVKISKDPS KIPSWLKVNKIYYPDFIVPDPKKAA VWEITGAEFSKSEAHTADGISIRFP RCTRIRDDKDWKSATNLPQLKELYQ LSKEKADFTVVAGDEGSSTTGGSSE ENKGPSGSAVSRKAPSKPSASTKKA EGKLSNSNSKDGNMQTAKPSAMKVG EKLATKSSPVKVGEKRKAADETLCQ TKVLLDIFTGVRLYLPPSTPDFSRL RRYFVAFDGDLVQEFDMTSATHVLG SRDKNPAAQQVSPEWIWACIRKRRL VAPC |
Purity : | >85%, by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 0.11 mg/mL |
Storage Buffer : | Supplied as a 0.2 μm filtered solution in PBS, pH 8.0. |
Gene Name : | LIG3 DNA ligase 3 [ Homo sapiens (human) ] |
Official Symbol : | LIG3 |
Synonyms : | LIG3; DNA ligase 3; LIG2; LIG3alpha; DNA ligase 3; ligase II, DNA, ATP-dependent; ligase III, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 3; EC 6.5.1.1 |
Gene ID : | 3980 |
mRNA Refseq : | NM_002311 |
Protein Refseq : | NP_002302 |
MIM : | 600940 |
UniProt ID : | P49916 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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