Recombinant Human LILRB1 protein, His-Avi-tagged

• Cat.No.: LILRB1-087H
• Product Overview: Human LILRB1 Protein is expressed from mammalian with His and Avi Tag at the C-terminal. It contains Gly24-His458.

Specification

• Description: LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 50 kDa .Due to glycosylation, the protein migrates to 72- 78KDa based on Bis-Tris PAGE result.
• Protein length: Gly24-His458
• Endotoxin: Less than 0.01EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: LILRB1 leukocyte immunoglobulin like receptor B1 [ Homo sapiens (human) ]
• Official Symbol: LILRB1
• Synonyms: CD85 antigen-like family member J; CD85j antigen; CD85j; Ig-like transcript 2; ILT2; ILT-2; ILT2FLJ37515; Immunoglobulin-like transcript 2; leukocyte Ig-like receptor-1; Leukocyte immunoglobulin-like receptor 1; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains); LILRB1; LIR1; LIR1LIR-1MIR-7CD85MIR7CD85 antigen; member 1; MIR7; Monocyte/macrophage immunoglobulin-like receptor 7
• Gene ID: 10859
• mRNA Refseq: NM_001081637.1
• Protein Refseq: NP_001075106.1
• MIM: 604811
• UniProt ID: Q8NHL6